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Szerzők:

• Woolf, CJ

Kiadás:

Kiadó: The Royal Society of Medicine Press
2001
International Congress and Symposium Series (ICSS) 248
ISBN 1-85315-476-8
ISSN 0142-2367

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Fülszöveg

The subject of this meeting, 'Antiepileptic drugs: mechanisms, modalities and clinical benefits', is a fascinating one, coverin~ a broad range of disorders of the nervous system. The programme includes few talks on epilepsy per se, and there is an evident mismatch between the term 'antiepileptic drugs' and the wide clinical utility of these agents. These compounds reduce normal excitability in the nervous system, epileptic discharge being only one extreme feature of this effect. The concept of control of abnormal excitability can therefore be expanded beyond epilepsy to a number of disorders characterized by abnormal neuronal excitability and thepe agents need to be considered as more than just antiepileptic drugs. A more fitting term might be 'antihypersensitivity agents'.
Antiepileptic drugs act on neuron excitability in a number of ways. Some   the classic membrane stabilizing agents   interfere with voltage gated sodium ion channels. Others affect synaptic transmission, acting presynaptically to prevent neurotransmitter production or release, or postsynaptically to block the binding of excitatory transmitters to their receptors. Some have novel modes of action, for example they may affect the way in which receptors and ion channels are modified by kinases. Finally, they may act by boosting or promoting inhibitory mechanisms in the nervous system, particularly the GABAergic system.
These drugs are, therefore, a broad class of compounds acting on divergent targets but with the common feature of control of neuronal excitability. Their use as treatment is a delicate balance between normalizing excitability without suppressing it to a level at which it interferes with normal function. The members of the faculty are experts in their respective fields and will provide insights into the mechanisms, modalities and potential clinical benefits of these drugs in epilepsy, neuropathic pain and several psychiatric indications. /PROFESSOR CLIFFORD J WOOLF